9. In a study, an undergraduate student discovered a new enzyme involved in the

Question

9. In a study, an undergraduate student discovered a new enzyme involved in the metabolism of serotonin. This enzyme is made up of 6 subunits of the same protein. To characterize this enzyme, the student carried out experiments to induce mutations in the coding region of the gene that codes for this protein. Which of the following graph would best represent mutations causing defective subunits? (Al represents the wild-type allele, A2 represents the mutant allele). A2A2 A1A2 A1A1 A2A2 A1A2 A1A1 LLJ A2A2 A1A2 A1A1 A2A2A1A2 A1A1

Explanation / Answer

The graph compares all three possible expression products in terms of enzymatic activity. The enzyme will only be active when all 6 subunits will fold into quaternary structure to give functional enzyme. If any of the subunits is missing or has incorrect sequence, it would not fold in correct configuration. Ultimately it will result in loos of enzymatic activity.

Answer B is a correct because defect in any of the subunits of enzyme would result in loss of its activity. Phenotypic expression is the formation of protein whether they are defective or functional that is measured by thier activity (graphs represent activity omnot phenotypic expression).

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