al Verizon 12:23 PM The following pedigree concerns two families, each with a hi

Question

al Verizon 12:23 PM The following pedigree concerns two families, each with a history of the same diease, a disease inherited as an autosomal recessive If individuals IV-3 and IV-4 marry, what is the probabilty that their first child will have the disease? If the diease is inherited as an autosomal dominant trait with 50% penetrance, then what would be the possibility that the first child from the marriage of IV3 and IV4 shows the disease? This trait has a probabilty of 0.0001 in the population in which these families live. If IV5 is married with a man who is also in this community, what is the probability that their first child has this trait?

Explanation / Answer

Autosomal recessive is one of several way that a trait, disorder, or disease can be passed down through families. Since, P(dominant)=50%

=1/2

Therefore, P(recessive)=1-1/2=1/2 [since P(E)+P(notE)=1]

Possibility that the first child shows disease=50%

The probability of trait in the specific population=0.0001

Trait of disease in IV5 is Dominent.

Therefore, The Probability that their First child has this trait =0.0001

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