tor Mediated Endocytosis estion 4-1. Upon binding its ligand, the EGF Receptor h

Question

tor Mediated Endocytosis estion 4-1. Upon binding its ligand, the EGF Receptor has been shown to undergo receptor mediated endocytosis. In this case the receptor is either recycled to the plasma membrane or is found in early endosomes. First, let's think about the structure of the EGF receptor. Part of the protein faces the outside of the cell and is used to bind EGF (Extracellular domain). Part of the protein is in the cytoplasm of the cell (kinase and C-terminus) and part of the protein crosses the membrane (transmembrane domain, TM). Which domain would have carbohydrates attached to it? Rubric (2): indicate one or more domains where you would expect to find carbohydrates on the protein TM63 9%-terminus|86 Kinase EGFR Extracelluar domain 044 1017 1005

Explanation / Answer

C domain site is actually posses carbohydrate binding site other then this ths distance between the substituted EGF domain( amino acid) residues and the 10 carbohydrate binding site within the lectin domain and there relative positioning can be determined by the three-dimensional crystal structure of the E-selectin lectin and EGF domains.

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