After reading the paragraphs below, answer the questions that follow Dilated car

Question

After reading the paragraphs below, answer the questions that follow Dilated cardiomyopathy (DCM) is a common cause of sudden death and heart failure. Many mutations can cause DCM, but several of them are linked to the protein troponin, which is an essential protein that helps regulate muscle contraction in the heart. Wild-type 3' ATGCGTTAGCTC 5' Mutant 3' ATGCTTTAGCTC 5 A mutation in troponin that has been linked to DCM is A159E, in which the amino acid A is replaced by the amino acid E. The middle portion of the exons (template strand of DNA) that contain the code for the wild-type A and the mutant E are shown in the accompanying table. Assuming that the reading frame starts with the first triplet, what is the codon for A? 5' GAA 3 5 ACG 3 5' AAG 3 5' GCA 3 Submit Request Answer

Explanation / Answer

Answer: Choice 4

Reason: According to the information, a single nucleotide substitution takes place for amino acid A with amino acid E. Thus, a codon sequence must have been changed in the wild type gene. It can be clearly seen from the data that the second codon i.e. CGT undergoes changed to CTT from wild type to mutant. The anticodon for the wild type gene is GCA and thus represents the site of mutation in the gene in complementary direction.

Related Questions

Navigate

• Browse (All)
• Browse A
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.