Why are some tissues damaged by diphtheria toxin while others are u affected by

Question

Why are some tissues damaged by diphtheria toxin while others are u affected by it? 1. Diptheria toxin is a super antigen. Only Th cells are affected by this type of toxin, so tissues lacking Th cells are unaffected. 2. The causative agent is inhaled into the lungs, so only lung tissue is affected by the toxin released by the organism. 3. Diptheria toxin is an A-B toxin. Cells that do not have a receptor for the toxin are unaffected by it. 4. The causative agent is infested, so only gastrointestinal tissue is affected by the toxin released by the organism. 5. Diptheria is a localized infection. Only tissues in the immediate area of the bacteria are affected by the toxin. Why are some tissues damaged by diphtheria toxin while others are u affected by it? 1. Diptheria toxin is a super antigen. Only Th cells are affected by this type of toxin, so tissues lacking Th cells are unaffected. 2. The causative agent is inhaled into the lungs, so only lung tissue is affected by the toxin released by the organism. 3. Diptheria toxin is an A-B toxin. Cells that do not have a receptor for the toxin are unaffected by it. 4. The causative agent is infested, so only gastrointestinal tissue is affected by the toxin released by the organism. 5. Diptheria is a localized infection. Only tissues in the immediate area of the bacteria are affected by the toxin. 1. Diptheria toxin is a super antigen. Only Th cells are affected by this type of toxin, so tissues lacking Th cells are unaffected. 2. The causative agent is inhaled into the lungs, so only lung tissue is affected by the toxin released by the organism. 3. Diptheria toxin is an A-B toxin. Cells that do not have a receptor for the toxin are unaffected by it. 4. The causative agent is infested, so only gastrointestinal tissue is affected by the toxin released by the organism. 5. Diptheria is a localized infection. Only tissues in the immediate area of the bacteria are affected by the toxin.

Explanation / Answer

3)Diptheria toxin is an A-B toxin. Diptheria toxin binding Domain (B) binds on host membrane. Membrane bound A+B toxin enters in membrane via endocytosis . Catalytic unit A cleaved with subunit B with disulphide bond. Catalytic A passes through membrane and elongate ADP ribosylate, this protein kill the cell

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