gure as an attach collecting duct in the kidney (part A) and the release of swea
ID: 300933 • Letter: G
Question
gure as an attach collecting duct in the kidney (part A) and the release of sweat from the sweat gland (B). ment depicts the concentration of urine in the Aquaporins (AQPs) play a role in both the short-term and long-term regulation of water balance as well as in the pathophysiology of water balance disorders 1. Describe the importance of AQP in these two processes and the effects of an AQP deficiency in each case. (1 pts) 2. How would you approach the drug development process? The drug should fix the abnormal process in the kidney related to the effect of an AQP (2 pts) ollecting duct lumen Concentrated urine 300 500 700?- ?????? Interstal 300 00 700 900 osmolality deficient -200 360 Water transport Near-isosmolar secreted fluid Salt 305 WaterExplanation / Answer
Ans
1)
AQP help in concentration of urine in kidney and deficiency of this leads to diabetes insipidus that is passing of dilute urine.
AQP helps in release of sweat from sweat gland and AQP -5 helps in this process and deficiency of this leads to accumulation of sweat in gland causing obstruction to duct.
Ans
2)
We should develop a drug that functions like aquaporin and can be given to patient to treat diabetes insipidus.
Ex. Desmopressin
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