A. GVH can result from MHC differences between donor and recipient B. GVH requir

Question

A. GVH can result from MHC differences between donor and recipient B. GVH requires donor cells that can activate the immune system C. GVH may result from the transfer of blood products that contain lymphocytes into 54. Which of the following statements regarding GVH(Graft vs Host) disease is incorrece the recipient's immune system. D. GVH requires natural killer cells E. G VH may occur in an immunosuppressed individual 55. Grafts between genetically identical individuals (i.e., identical twins) A. are rejected slowly as a result of minor histocompatibility antigens. B. are subject to hyperacute rejection. C. are not rejected, even without immunosuppression. D. are not rejected if a kidney is grafted, but skin grafis are rejected. 56. The role of the macrophage during an antibody response is to A. make antibody B. lyse virus-infected target cells. C. activate cytotoxic T cells D. process antigen and present it. 57. Method of treatment to help transplanted organs survive because it blocks the co-stimulation step required in B-c ell activation A. Rapamycin B. Anti-CD3 C Cyclosporin A D. Mab-IgE E. CTLA-4lg 58. Hemolytic disease of the newbormn requires maternal antibody to enter the fetal bloodstream. Therefore, the mediator of this disease is A. IgE antibody. B. IgG antibody. C. IgM antibody D. IgA antibody 59. Which one of the following is the BEST method of reducing the effect of graft-versus-host disease in a bone marrow recipient? A. matching the complement components of donor and recipient B. administering alpha interferon C. removing mature T cells from the graft D. removing pre-B cells from the graft

Explanation / Answer

55) Unless donor and recipient bare identical twins ,all grafts recipients must be given immunosuppressive drugs to prevent rejection.Indeed,the current success of clinical transplantation of solid organs is more the result of advances in immunosuppressive therapy.so,C is the correct option

56) The role of macrophage is to..the generation of an effective immune response requires the antigen to be processed by APC ( antigen presenting cells) ,which are then presented to the T cells or T lymphocytes. so D is the correct option.

57) CTLA4Ig prevents naive T cell activation by binding to B7 proteins and blocking the enhancement.Inhibits effector T cells .

58) Hemolytic disease also known as erythroblastosis fetalis is an alloimmune condition that develops in fetus ,when the IgG molecule ( one of the 5 main type of antibodies) produced by the mother pass through the placenta .so B is the correct option .

59) GvH disease develops when donor and person receiving donor cells have different tissue type.So matching the complement components of donor and recipient is the best way.

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