12)72018 More v 3 Take Home (Ch 12 14 15 16 17 18 19) ermani Hayes: Attempt 1 Ho
ID: 301954 • Letter: 1
Question
12)72018 More v 3 Take Home (Ch 12 14 15 16 17 18 19) ermani Hayes: Attempt 1 How does the insulin receptor differ from the erythropoietin receptor? Upon binding its signal molecule, the insulin receptor has two-fold symmetry, while the erythropoietin receptor does not. The insulin receptor contains a tyrosine kinase, while the erythropoetin receptor does b) c) Both the insulin and erythropoietin receptors trigger MAPK cascades. d) not. The insulin receptor is phosphorylated in response to signal molecule binding, while the erythropoietin receptor does not. 26 AM 7/28/2018 ?? archExplanation / Answer
Answer is (c)
They both show two fold symmetry upon binding of signal molecule.
Both of them have tyrosine kinase activity. Insulin has tyrosine kinase domain in the cytoplasmic portion to trigger MAPK signaling directly, whereas erythropoetin has JAK2 protein in cytoplasmic portion and mediates MAPK pathway via JAK2-STAT5 pathway.
They both show tyrosine residue phosphorylation in response to signal molecule binding.
Related Questions
Navigate
Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.