s11 T-Mobile Wi-Fi? 2:21 AM Meme Kee bodies are formed when the glucagon/insulin
ID: 301962 • Letter: S
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s11 T-Mobile Wi-Fi? 2:21 AM Meme Kee bodies are formed when the glucagon/insulin ratio is high d) During prolonged starvation, the brain adapts to using ketone bodies as a fuel. e) Excess acetone production during ketoacidosis is exhaled through the lungs. uestion 49 (1 point) Which statement is TRUE regarding the regulation of pyruvate kinase? al Acetyl-CoA is an allosteric activator of pyruvate kinase M. Funtoya o bphisphitets tedfoward aloterk insibitorof both prunate kinase Only in liver tissue is alanine an ChREBP Which is activated in the presence xylulase 5-phosphate, is a transcription kinase L ic inhibitor of pyruvate kinase d) factor that is associated with an activity of pyruvate kinase in the fiver MacBook Air 8 5 0Explanation / Answer
The followig statement is TRUE regarding the regulation of pyruvate kinase:
ChREBP,which is activated in the presence xylulose 5-phosphate,is a transcription factor that is associated with an increase in transcription of the gene for pyruvate kinase L.
Pyruvate kinase is the enzyme that catalyzes the final step of glycolysis.It catalyses the transfer of phosphate group from the Phosphoenolpyruvate(PEP) to adenosine diphosphate(ADP),yielding one molecule of pyruvate and one molecule of ATP.
ChREBP is found to be an essential protein in gene transcription of the L isozyme pyruvate kinase.The domains of ChREBP are target sites for regulation of pyruvate kinase by glucose and cAMP.Specifically,ChREBP is activated by a hig concentration of glucose and inhibited by cAMP.Glucose and cAMP work in opposition with one another through covalent modifier regulation.While cAMP binds to Ser196 and Thr666 binding sites of ChREBP,causing the phosphorylation and inactivation of pyruvate kinase,glucose binds to Ser196 and Thr666 binding sites of ChREBP,causing the dephosphorylation and cati ation of pyruvate kinase.As a result,cAMP and excess carbohydrate are shown to play an indirect role in pyruvate kinase regulation.
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