35. three variant of the gene encoding the b globin components of hemoglobin occ

Question

35. three variant of the gene encoding the b globin components of hemoglobin occur in the human population of the kassena nankana district of ghana west africa the most frequent allele occurs at frequency 0.38 . the two other variants S and C occur at frequency 0.04 and 0.13 respectively each individual has two alleles determining its genotype at the b globin gene. assume that knowing the identity of one of the allele of any individual provides no information about the identity of the second allele. ?

a) CC individuals, having two copies of allele C, are slightly anemic. what is the probability that a randomly sampled individual from the population has two copies of the C allele (in other words whta is the probabilty that the individual's first allele is C and his or her second allele is also C )?

b) What is the probability that a randomly sampled individual is a homozygote ( has two copies of the same allele)?

c) Compared with AA individuals, AS and AC individual are largely resistant to malaria, which is endemic. To the region. They also experience fewer deleterious side effects than SS and CC individuals, what is the probability that a randomly sampled individual is AS?

d) What is the probability that a randomly sampled individual is AS or AC ?

Explanation / Answer

a)

Probability will be 0.13 * 0.13 = 0.0169

b)

probability = 0.38*0.38 + 0.04*0.04 + 0.13*0.13 = 0.1629

c)

what is the probability that a randomly sampled individual is AS?

Probability = 0.38 * 0.04 = 0.0152

d)

d) What is the probability that a randomly sampled individual is AS or AC ?

Probability = 0.38*0.04 + 0.04*0.13 = 0.0204

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