need a question for problem 2 question a Problem 2 Gram-negative bacterium Vibri
ID: 302881 • Letter: N
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need a question for problem 2 question a
Problem 2 Gram-negative bacterium Vibrio cholera produces a protein (cholera toxin) that is responsible for cholera symptoms: extensive loss of water and Na through continuous diarrhea, which can be fatal. The toxin tightly binds specific sites on the plasma membrane of intestinal cells, where it prolongs the activation of adenylate cyclase (AC). Questions: A. (3 pts) What effect does the cholera toxin have on cAMP levels in intestinal cells? B. (3 pts) Based on the provided information: suggest a role for cAMP in intestinal cells under normal conditions. (Problem 3 on next page!)Explanation / Answer
Once the toxin enters the intestine it enters the enterocite.thr the A1 fragment of the toxin enters the cytosol, it activates the G protein through ADP ribosylation to lock the G protein in it's GTP bound form by stimulating adenylate cyclase to produce CAMP.
This CAMP leads to infection and causes increased water in the small intestine and leads to watery diarrhea.
When the membrane enzyme adenylyl cyclase is activated..the cyclic AMP goes on the activate specific proteins kinase A.
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