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10.34 Cancer-detecting dogs. Research has shown that some biochemical markers ar

ID: 3058389 • Letter: 1

Question

10.34 Cancer-detecting dogs. Research has shown that some biochemical markers are found exclusively in the breath of patients with lung cancer. However, no lab test can currently distinguish the breath of lung cancer patients from that of other subjects Could dogs be trained to identify these markers in specimens of human breath, just as they can be trained to detect illegal substances or to follow a person's scent? Am experiment trained dogs to distinguish breath specimens of lung cancer patients from breath specimens of control individuals by using a food-reward training method. After the training was complete, the dogs were tested on new breath specimens without any reward or clue using a double-blind, completely randomized design. Here are the results for a random sample of 1286 breath specimens Breath specimen from a Total Dog test result Negative Positive Total Cancer subject 10 564 574 Control subject 708 568 712 1286 (a) The sensitivity of a diagnostic test is its ability to correctly give a positive result when a person tested has the disease, or P(positive test disease). Find the sensitivity of the dog cancer-detection test for lung cancer. The specificity of a diagnostic test is the conditional probability that the test comes up negative, given that the subject tested doesn't have the disease. Find the specificity of the dog cancer-detection test for lung cancer (b)

Explanation / Answer

10.34 Cancer-detecting dogs. Research has shown that some biochemical markers are found exclusively in the breath of patients with lung cancer. However, no lab test can currently distinguish the breath of lung cancer patients from that of other subjects Could dogs be trained to identify these markers in specimens of human breath, just as they can be trained to detect illegal substances or to follow a person's scent? Am experiment trained dogs to distinguish breath specimens of lung cancer patients from breath specimens of control individuals by using a food-reward training method. After the training was complete, the dogs were tested on new breath specimens without any reward or clue using a double-blind, completely randomized design. Here are the results for a random sample of 1286 breath specimens Breath specimen from a Total Dog test result Negative Positive Total Cancer subject 10 564 574 Control subject 708 568 712 1286 (a) The sensitivity of a diagnostic test is its ability to correctly give a positive result when a person tested has the disease, or P(positive test disease). Find the sensitivity of the dog cancer-detection test for lung cancer. The specificity of a diagnostic test is the conditional probability that the test comes up negative, given that the subject tested doesn't have the disease. Find the specificity of the dog cancer-detection test for lung cancer (b)

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