Health Informatics Question: 1. What factor has the highest relative risk for wo

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Health Informatics Question:

1. What factor has the highest relative risk for women (Table 4). What has the second highest relative risk ratio? What two coefficients (table 5) have the largest impact on the prediction?

TABLE 4. Multivariable-Adjusted Relative Risks for CHD According to TC Categories

Men                                       Women

Relative Risk

95% CI

Relative Risk

95% CI

Age, y

1.05‡

1.04–1.06

1.04‡

1.03–1.06

Blood pressure

Normal (including optimal)

1.00

Referent

1.00

Referent

High normal

1.31

0.98–1.76

1.30

0.86–1.98

Hypertension stage I

1.67†

1.28–2.18

1.73†

1.19–2.52

Hypertension stage II–IV

1.84‡

1.37–2.49

2.12†

1.42–3.17

Cigarette use (y/n)

1.68‡

1.37–2.06

1.47†

1.12–1.94

Diabetes (y/n)

1.50*

1.06–2.13

1.77†

1.16–2.69

TC, mg/dL

<200

200–239

1.00

1.31*

Referent

1.01–1.68

1.00

1.51*

Referent

1.01–2.24

Š240

1.90‡

1.47–2.47

1.72†

1.15–2.56

HDL-C, mg/dL

<35

1.47†

1.16–1.86

2.02†

1.29–3.15

35–59

1.00

Referent

1.00

Referent

Š60

0.56†

0.37–0.83

0.58†

0.43–0.79

The multivariate models were performed separately for men and women. Each model included simultaneously all variables listed in the table. All analyses used categorical variables.

*.01<P<.05, †.001<P<.01, ‡P<.001.

TABLE 5. Multivariate-Adjusted Relative Risks for CHD According to LDL-C Categories

Men                                      Women

Relative Risk

95% CI

Relative Risk

95% CI

Age, y

1.05‡

1.04–1.06

1.04‡

1.03–1.06

Blood pressure

Normal (including optimal)

1.00

Referent

1.00

Referent

High normal

1.32

0.98–1.78

1.34

0.88–2.05

Hypertension stage I

1.73‡

1.32–2.26

1.75†

1.21–2.54

Hypertension stage II

1.92‡

1.42–2.59

2.19‡

1.46–3.27

Cigarette use (y/n)

1.71‡

1.39–2.10

1.49†

1.13–1.97

Diabetes (y/n)

1.47*

1.04–2.08

1.80†

1.18–2.74

LDL-C, mg/dL

<130

1.00

Referent

1.00

Referent

130–159

1.19

0.91–1.54

1.24

0.84–1.81

Š160

1.74‡

1.36–2.24

1.68†

1.17–2.40

HDL-C, mg/dL

<35

1.46†

1.15–1.85

2.08†

1.33–3.25

35–59

1.00

Referent

1.00

Referent

Š60

0.61*

0.41–0.91

0.64†

0.47–0.87

The multivariate models were performed separately for men and women. Each model included simultaneously all variables listed in the table. All analyses used categorical variables.

*.01<P<.05, †.001<P<.01, ‡P<.001.

See Tables:

Explanation / Answer

Hypertension stage II-IV has the highest relative risk for women with the value of 2.12

The second highest relative risk ratio for women is for HDL-C, <35 group with the value of 2.02

Based on table 5 the two coefficients having the largest impact on prediction having P<0.001 are age and hypertension - stage II having p-values less than 0.05 for both men and women.

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