Use the mutation lab to answer the question below. Which two of the following su

Question

Use the mutation lab to answer the question below. Which two of the following substitution mutations most strongly affects the protein? Mark two choices. changing T to A within the DNA segment TGC near the middle of the strand changing A to T within the DNA segment TAC near the start of the strand changing C to A within the DNA segment TGC In the middle of the strand changing G to C within the DNA segment GTA near the start of the strand changing C to T within the DNA segment AAC near the end of the strand changing A to C within the DNA segment ATC near the end of the strand

Explanation / Answer

Answer

The start site of the DNA strand is always on ATG and the ones which are at the stop site can either be TAA, TAG, or TGA. Any changes in these can lead to mutations and can be detrimental for transcription to take place as RNA polymerase has high complementarity for these sequences. Furthermore, the change in the nucleotide sequence can alters the synthesis of amino acids causing detrimental changes in the main sequence. Thus, the correct statements are:

option (b) changing A to T within the DNA segment TAC near the start of the strand

option (f) changing A to C within the DNA segment ATC near the end of the strand

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