AURALGAN Otic Drops contain: Antipyrine 5.4% Benzocaine 1.4% Acetic acid 0.01% u

Question

AURALGAN Otic Drops contain: Antipyrine 5.4% Benzocaine 1.4% Acetic acid 0.01% u-polycosanol 410 0.01% Glycerin, ad 10 mL (a) What would be the content of antipyrine, in mg/mL? Solutions: (b) If a patient used 5 drops of the otic solution, equivalent to 0.25 mL, how many milligrams of benzocaine would have been administered? Solutions: (c) How many mu L of acetic acid would be used to prepare the 10 mL of drops? Solutions: (d) What would be the equivalent ratio strength (v/v) of u-polycosanol 410? Solutions:

Explanation / Answer

Ans. #a. Given, antipyrine content = 5.4 %. That is, there is 5.4 g antioyrine per 100.0 mL of the solution. [Its assumed that the strength is given in terms of % w/v.]

So, content of antipyrine = 5.4 g / 100 mL

                                                = 5400.0 mg/ 100 mL                                  ; [1 g = 1000 mg]

                                                = 54.0 mg/ mL

#b. Given, benzocaine content = 1.4 % (w/v) = 1.4 g/ 100.0 mL

Now,

Amount of benzocaine in 0.25 mL = 1.4 % of 0.25 mL                           ; [ 1% = 1/100]

                                                = (1.4 g / 100.0 mL) x 0.25 mL

                                                = 0.0035 g

                                                = 3.50 mg                

#c. Note: Acetic acid is naturally present in liquid state and its density is lower than that of water. Since the question does not mention its density, it’s assumed that content of acetic acid is in terms of % (v/v).

Given, acetic acid content = 0.01 % (w/v) = 0.01 g/ 100.0 mL

Now,

Volume of acetic acid in 10.0 mL solution = 0.01 % of 10.0 mL                                  

                                                = (0.01 mL / 100.0 mL) x 10.0 mL

                                                = 0.001 mL

                                                            = 1.000 ug                                        ; [1 mL = 1000 ug]

#d. u-polycosanol 410 content = 0.01 %

                                                            = 0.01 mL / 100 mL

                                                            = 1 / 10000

The ‘equivalent ratio strength’ of a component represents the ration of 1 part of the component (here, u-polycosanol) to the respective amount of solution that exactly would contain 1 part of the component.

Since 1 part (by volume) of the u-polycosanol 410 is contained in 10000 part (by volume) of solution, the equivalent strength of it is 1/10000 (v/v).

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