A prescription calls for 50 mg of chlorpheniramine maleate. Using a prescription

Question

A prescription calls for 50 mg of chlorpheniramine maleate. Using a prescription balance with a sensitivity requirement of 6 mg, explain how you would obtain the required amount of chlorpheniramine maleate with an error not greater than 5%. A prescription balance has a sensitivity requirement of 0.006 g. Explain how you would weigh 0.012 g of a drug with an error not greater than 5%, using lactose as the diluent. A torsion prescription balance has a sensitivity requirement of 4 mg. Explain how you would weigh 5 mg of hydromorphone hydrochloride with an error not greater than 5%. Use lactose as the diluent. A torsion prescription balance has a sensitivity requirement of 0.004 g. Explain how you would weigh 0.008 g of a substance with an error not greater than 5%. A prescription balance has a sensitivity requirement of 6.5 mg. Explain how you would weigh 20 mg of a substance with an error not greater than 2%. Sodium citrate 5g Tartar emetic 0.015 g Cherry syrup ad 120 mL Using a balance with a sensitivity of 4 mg, an acceptable weighing error of 5% and cherry syrup as the solvent for tartar emetic, how could you obtain the correct quantity of tartar emetic to fill the prescription?

Explanation / Answer

The Class III Balance has a sensitivity requirement of 6 mg, meaning that as much as 6 mg could be added to or removed from the pan before the balance marker will move 1 division.

We first measure out 120mg of drug, and then we dilute it with 1380mg of the lactose. The total weight is 1500mg with 120mg of drug in it.

To deliver 0.012grams or 12mg we take 1/10 of this solution that is administer 150mg of the solution.

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