The degree of freedom table is available online. Please answer A&B for question

Question

The degree of freedom table is available online. Please answer A&B for question 2

In humans, the dominant allele N causes an abnormal shape of the patella in the knee (n is the normal allele). A separate gene affects finger length, and the dominant allele B causes abnormally short fingers, whereas b gives normal length. A study focused on people who have both abnormal patellae and short fingers (they most likely have the genotype N/n B/b). They inherited the N allele from one parent and the B allele from the other parent. These N/n B/b individuals mated with normal spouses. (The spouses had no history of abnormal patellae or short fingers in their families; they can be assumed to be homozygous normal.) 40 progeny were boom; they are classified as follows. Using the chi square test, determine whether there is significant linkage between the B/b and the N/n gene. X^2 = P = linked? If you conclude there is linkage, what is the distance between the two genes?

Explanation / Answer

Answer:

a). N/n; B/b x n/n; b/b

N/n B/b : N/n b/b ; n/n B/b ; n/n b/b

1:1:1:1

Chi-square vale = 22.60

The degrees of freedom = 4-1 = 3

p value = 0.00004893

The genes are not linked

Phenotype Observed(O) Expected (E) O-E (O-E)2 (O-E)2/E Normal 3 10 -7 49.00 4.90 Abnormal knees and fingers 2 10 -8 64.00 6.40 Abnormal knees only 17 10 7 49.00 4.90 Abnormal fingers only 18 10 8 64.00 6.40 40 22.60

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