1.A case-control study is conducted to assess the relationship between heavy alc

Question

1.A case-control study is conducted to assess the relationship between heavy alcohol use during the first trimester of pregnancy and miscarriage. Fifty women who suffered miscarriage are enrolled along with 50 who delivered full term. Each participant’s use of alcohol during pregnancy is ascertained. Heavy drinking is defined as 4 or more drinks on one occasion. The data are shown below.

Miscarriage

Delivered Full Term

Heavy Alcohol Use

14

4

No Heavy Alcohol Use

36

46

Compute the odds of miscarriage in women with heavy alcohol use in pregnancy.

Odds Heavy Use = ________

Compute the odds of miscarriage in women with no heavy alcohol use in pregnancy.

Odds No Heavy Use ________

Compute is the odds ratio for miscarriage as a function of heavy alcohol use.

Odds Ratio = ________

Miscarriage

Delivered Full Term

Heavy Alcohol Use

14

4

No Heavy Alcohol Use

36

46

Explanation / Answer

Odds Heavy Use = 14 /82

Odds No Heavy Use=36/82

odds ratio= (14*46) / (36*4)= 4.472

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