One could think about the steps that occur after the release of ACh into the syn

Question

One could think about the steps that occur after the release of ACh into the synapse and result in the power stroke as a series of protein conformational changes – what proteins change conformation, in what location, and in response to what stimuli? In your response, provide a list of 5 proteins (ion channels, regulatory molecules, and filaments) IN THE CORRECT ORDER in the following format:

Protein 1 – in location 1 – in response to stimulus 1

Protein 2 – in location 2 – in response to stimulus 2

Explanation / Answer

Due to nicotine, Ach is released and it binds to Ach binding protein (protein 1) - alpha subunit of cholinergic receptor - in response to which ion channels are open , permitting either one or more specific type of ions (K+ Na+ Ca++) to diffuse in to or out of the cell.

Ach when binds to protein 2 , muscarine Ach receptor - having 5 subunit, M1, M3, M5 receptor causes activation of phospholipase C - in response secondary messenger (IP3 and DAG) released - eventually leading to an intracellular increase of Calcium while M2,M4 inhibits adneylate cyclase, thereby decreaseing the production of secondary messenger cAMP . The activation of M2 receptor in heart is important for closing Calcium channel in order to reduce the force and rate of contraction.

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