Read the following abstract, then answer the questions below: Lipids Health Dis.
ID: 3164665 • Letter: R
Question
Read the following abstract, then answer the questions below: Lipids Health Dis. 2018 Mar 27;17(1):61. doi: 10.1186/s12944-018-0705-9 Alzheimer-like brain metabolic and structural features in cholesterol-fed rabbit detected by magnetic resonance imaging 1,2 3 4 Author information 1 The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54 Youdian Road, Shangcheng District, Hangzhou, Zhejiang, 310006, People's Republic of China. 2- The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China. 3 - Laboratory Animal Research Center/Comparative Medical Research Institute, Zhejiang Chinese Medical University, No 548 Binwen Road, Binjiang District, Hangzhou, 310053, China. 4 - Laboratory Animal Research Center/Comparative Medical Research Institute, Zhejiang Chinese Medical University, No 548 Binen Road, Binjiang District, Hangzhou, 310053, China. cmli991@aliyun.com. 5 The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54 Youdian Road, Shangcheng District, Hangzhou, Zhejiang, 310006, People's Republic of China. xums166@zcmu.edu.cn. Abstract BACKGROUND: Hypercholesterolemia is known to increase the risk of AD in later life, the purpose of this study is to illustrate brain metabolic and structural changes in a cholesterol-fed rabbit model of Alzheimer's Disease(AD) by using clinical 3 T Magnetic Resonance Imaging (MRI). METHODS: The Institutional Animal Care and Use Committee of Zhejiang Chinese Medical University approved the study. Totally 16 Japanese White Rabbits (JWR) were randomly divided into 2 groups including normal control group fed with routine diet group NC) and high cholesterol dietgroup (group CD) fed a 2% cholesterol dietwith 0.24 ppm copper in the drinking water for 12 weeks. Magnetic resonance spectroscopy (MRS) and structural image of rabbit brain were performed by using a 3 Tesla (T) MRI scanner with an 8 channel Rabbit coil. The chemical metabolites were identified by LC Model including N acetylaspartate (NAA), creatine (Cr), glutamate (Glu), glutamine (GIn), Glycerophosphatidylcholine (GPC), phosphorylcholine (PCH), and myoinositol (MI). The relative concentrations (/Cr) were analyzed. Additionally, Amyloid-? (AB) accumulation in the brain was measured postmortem. For comparisons of MR and Aß data between groups, two-tailed t-tests were performed RESULTS: The ratio of NAA/Cr (0.76±0.10) and Glu/Cr (0.90±0.14) in group CD were lower than those in the group NC (0.87±0.06, 1.13±0.22, respectively, PExplanation / Answer
1. The corresponding author is the first author Jin P. Who would be contact for any correspondence. And the authors who likely funded this are Sun z, and Pan Z.
2. The authors did this study is to see what changes occurred in the brain of rabbits who are fed cholesterol diet. This was used to confirm since hyper cholestemia had been known to be increasing Alzheimer’s risk later on in life.
3. The study checks the changes that take place in the brain as a result of high fat diet that would be leading to development of Alzheimer’s.
4. High cholesterol diet induced structural and metabolic changes in the brain.
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