Purebred dogs are susceptible to many genetic disorders. Cocker spaniels, in par

Question

Purebred dogs are susceptible to many genetic disorders. Cocker spaniels, in particular, are prone to a disorder called canine phosphofructokinase (PFK) deficiency, an autosomal recessive condition in which glucose is unable to be metabolized into available energy. Because the PFK enzyme is important for energy metabolism in red blood cells and skeletal muscle during exercise, a deficiency in the enzyme results in exercise intolerance and muscle disease.

Use the pedigree below, which shows the inheritance of PFK deficiency in cocker spaniels, to answer the questions.

Part A

If wild-type GALT is designated as G and the recessive allele is designated as g, determine the genotypes of the following individuals.

Drag a genotype to each individual in the pedigree. Labels may be used more than once or not at all.

Explanation / Answer

If wild-type GALT is designated as G and the recessive allele is designated as g, the genotypes are determined as the following for individuals.

Jean - gg

Patrica - GG

Les - Gg

John - gg

Mary - G_

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