please summary this paragraph about ((Role of SIN3 HDAC Complex Components in Re
ID: 3165195 • Letter: P
Question
please summary this paragraph about ((Role of SIN3 HDAC Complex Components in Recruitment to Chromosomes).?
In eukaryotic organisms, regulation of gene expression at the transcriptional level can be achieved through post-translational modifications of histones, proteins complexed with DNA. The SIN3 histone deacetylase (HDAC) complex is one such regulator of gene expression. It removes acetyl groups from N-terminal histone tails, resulting in formation of compact chromatin structure and repression of transcription. The SIN3 HDAC complex is conserved from yeast to mammals and has been implicated in several studies of disease characterized by aberrant patterns of gene expression. To elicit its repressive role on gene expression, SIN3 must be recruited to promoter regions of genes. SIN3 is unable to achieve its repressive function alone as it does not possess a DNA binding domain or enzymatic activity. Instead, SIN3 acts as a scaffolding protein for other components of the SIN3 complex, which include histone deacetylases and proteins that mediate interactions between SIN3 and DNA-binding proteins, allowing for its recruitment to specific regions of the genome.
Explanation / Answer
SIN3 histone deacetylase complex is a regulator of gene expression which consist of SIN3 scaffolding protein, histone deacetylase and other proteins. SIN3 deacetylase complex regulate the gene expression by removal of acetyl groups from N-terminal of histone proteins complexed with DNA molecule resulting in formation of compact structure of cromatiin and thus repression of gene expression occurs (expression of gene require loosly arranged chromatin structure). To elicit its repressive action on gene expression first of all SIN3 protein of this complex recruited at the promoter region of gene which act as scaffold for histone deacetylase and other proteins that mediate interactions between SIN3 and DNA-binding proteins, allowing for its recruitment to specific regions of the genome.
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