37) Below are the wild type amino acid sequence for a short protein and the sequ

Question

37) Below are the wild type amino acid sequence for a short protein and the sequence for a mutant version of the same protein. Identify the change(s) at the DNA level (coding strand) that would result in the mutant. Indicate the type of nucleotide change(s) (transition, transversion, insertion, deletion) and the effect(s) on the protein (neutral, missense, etc.). Use the space provided to show your work (2 marks). Wild type: Met -Gly -Glu -Thr-Asn -Val -Pro Mutant: Met -Gly -Glu -Tyr Change at DNA level Effect on protein

Explanation / Answer

Chnage at DNA level - a) deletion of codons (last 4 amino acids)

                                      b) insertion of codons for TYR

Effect on protein - as the whole protein sequence has changed so the protein will loose its native structure. the change in structure will cause non-functional protein.

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