Question 11 2 pts The critical concentration (Cc) for microfilament in test tube

Question

Question 11 2 pts The critical concentration (Cc) for microfilament in test tube is around 0.2 uM. The cellular concentration of actin is above 20 uM, far greater than Cc of microfilament. F-actin elongation is not prevalent inside of living cells. Which of the following can explain this discrepancy? In living cells, most of Actin is loaded with ADP OMost of Actin monomers are not available for polymerization in living cells. O In living cells, treadmilling effect largely limits microfilament growth At a concentration above Cc, elongation reaction is not favorable

Explanation / Answer

The answer is option 3. Due to the treadmilling effect the net length of the filament remains unchanged. Actin subunits are recruited from a pool of inactive filaments by a protein called profilin.Its activity is regulated so that its taken up only when needed.

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