QUESTION 3 I. Pormation of dowble-stranded RNAs inside of the cell activates the

Question

QUESTION 3 I. Pormation of dowble-stranded RNAs inside of the cell activates the RNA interfernce mechanisns involving the enzyme compleses DICER and RISC, leading to the destruction or inactivation of target mRNAs. How is RISC, gpided to the mRNA that is to be destruyed or inactivated? r A There is a RNA-binding protein in RISC which recognizes the consensus sequence in the target mRNA RISC Includes ribasomal proteins and RNAs which bind to the Shine Delgarno sequences othe MRNAs ? ? The strand of the double-stranded RNA that is complementary to the sequences of specific DTwo of the above E All of the above. .5 points QUESTION 4 1. You are testing a drug which blocks the activity of histone acetyltransferases in eukaryotic cells In general what do you expect to observe with regards to the chromatin and gene expression in treated cells? r A The chromatin near cis regulatory sequences will be more open and less gene transcription would · The chromatin near cis regulatory sequences will be more open and more gene transcrip on would C C The chromatin near cis regulatory sequences will be more closed and less gene trarescriptian would C D The chromatin near cis-regulatory sequences will be more closed and more gene transcription would r & There would he no effect on chromatin or gene transcription. HATs are involved in regulating the assembly of histoses

Explanation / Answer

3. Option C is correct.

RISC complex is common to all small RNAs. The specificity of target recognition is provided by the complementary sequence of the small RNA.

4. Option C is correct.

Histone acetyltransferase activates gene expression by adding acetyl groups to histone tails thereby loosening the chromatin. If a drug is used to block HAT, the chromatin becomes more closed and transcription will be halted/reduced.

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