A scientist studied the efficacy of all the treatments for post-traumatic stress

Question

A scientist studied the efficacy of all the treatments for post-traumatic stress disorder PTSD. Scientific research databases were searched for randomized controlled clinical trials of any treatment for PTSD in adults Articles slected were these in which all subjects were adults with a diagnosis of PTSD. The sample consisted of 137 treatment comparisons from 112 studies and the data was synthesized. Which two factors would limit the application of this data? 1) substantial difference in study design and praticipant traits. 2) the lack of differences in the study design and participant traits, 3) The larger effects on the female sample. 4) The variety of treatment options. Please explain the answer in detail.

Explanation / Answer

1) substantial difference in study design and praticipant traits.

4) The variety of treatment options.  

because there are major difference ints design and its participants traits

also they have variety of treatment options to cure one design

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