Receptor tyrosine kinases (you may want to review this family of receptors) have

Question

Receptor tyrosine kinases (you may want to review this family of receptors) have a ligan-binding domain on the outside of a cell and a kinase domain on the inside of the cell. Select all tru statements: (SELECT ALL THAT APPLY)

A- Antibodies can be used to block the ligand-binding domain

B- Antibodies can be used to block the activity of the kinase domain

C- ATP and its analogs bind the kinase domain

D- The signal (ligand binding) is often transduced through dimerization of the receptor

E- Upon ligand binding the receptors localize to the nucleus to change gene expression

F- Because they have extracellular domains, hydrophilic drugs can easily target these receptors

Explanation / Answer

C- ATP and its analogs bind the kinase domain

D- The signal (ligand binding) is often transduced through dimerization of the receptor

F- Because they have extracellular domains, hydrophilic drugs can easily target these receptors

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