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The following reactions convert glycerol to dihydroxyacetone phosphate. Given th

ID: 322211 • Letter: T

Question

The following reactions convert glycerol to dihydroxyacetone phosphate. Given these reactions, how many molecules of ATP (or equivalent) would be produced by the complete aerobic catabolism of one molecule of glycerol to CO2 and H2O? (Assume that re-oxidation of NADH via the electron transport chain yields the equivalent of 3 ATP, and that re-oxidation of FADH2 yields 2 ATP.)

glycerol + Pi ---------> glycerol-3-phosphate

glycerol-3-phosphate + NAD+ -------> NADH + H+ + dihydroxyacetone phosphate

a.23

b.17

c.20

d.25

glycerol + Pi ---------> glycerol-3-phosphate

glycerol-3-phosphate + NAD+ -------> NADH + H+ + dihydroxyacetone phosphate

a.23

b.17

c.20

d.25

Explanation / Answer

glycerol + Pi ---------> glycerol-3-phosphate

glycerol-3-phosphate + NAD+ -------> NADH + H+ + dihydroxyacetone phosphate

a.23-

b.17----------answer

c.20

d.25

============================================

explanation

Total ATP from glycerol

            Conv. To DHAP                     -1 ATP                                                Total:

                                                            +1 NADH (cytoplasmic)        11 ATP

            glycolysis                                +1 NADH(cytoplasmic)         2 NADH (cytoplasmic)

                        (enters halfway)          +2 ATP                                   1 NADH

            Pyruvate met.                          +1 NADH

            Krebs, etc.                               + 10 ATP

                                    11 + (2 x 2.5 if liver, heart, kidney) + (1 x 2.5) = 18.5 ATP

                                    11 + (2 x 1.5 if brain or muscle) + (1 x 2.5 ) = 16.5 ATP

Total ATP from glycerol backbone = 18.5 – 16.5 ATP

-=====================================

glycerol + Pi ---------> glycerol-3-phosphate

glycerol-3-phosphate + NAD+ -------> NADH + H+ + dihydroxyacetone phosphate

a.23-

b.17----------answer

c.20

d.25

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