The mechanism of c-myc gene conversion to an oncogene include: a. loss of hetero

Question

The mechanism of c-myc gene conversion to an oncogene include:

a. loss of heterozygocity (LOH)

b. a point mutation causing constitutive activity

c. a point mutation causing loss of function

d. gene amplification

Retinoblastoma (Rb) gene mutations resulting in cancer include

a. an inactivating mutation in just one of the two alleles

b. gene amplification

c. retrovirus insertion upstream of the promoter

d. loss of heterozygocity (LOH) through mitotic recombination

e. a loss of DNA methylation in the gene promoter region

Explanation / Answer

The mechanism of cancer in c-myc gene is gene amplification.. It is being found that in many cases it is due to the over expression of this gene which causes cancer...

In case of retinoblastoma it causes cancer due to the inactivity mutation in just one of the two alleles of Rb1 which when passed from the heridetary to heridetary..

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