Attributable Risk A hypothetical cohort study looked at the association between
ID: 3272554 • Letter: A
Question
Attributable Risk
A hypothetical cohort study looked at the association between family history and the risk of developing Alzheimer’s disease. The results were as follows:
Alzheimer’s Disease
No Alzheimer’s Disease
Totals
Incidence of AD
Family History
50
1,950
2,000
25 per 1,000
No Family History
25
2,975
3,000
8.3 per 1,000
2. Assume the prevalence of family history in the general population is 5%. Calculate the population attributable risk and interpret it in words. (must show work)
Alzheimer’s Disease
No Alzheimer’s Disease
Totals
Incidence of AD
Family History
50
1,950
2,000
25 per 1,000
No Family History
25
2,975
3,000
8.3 per 1,000
Explanation / Answer
here relative risk RR=25/8.33 =3
and prevalence P =0.05
therefore population attributable risk =P(RR-1)/(1+P(RR-1)) =0.05*(3-1)/(1+0.05*(3-1))=0.0909
which represent that 9.09% of Alzheimer’s Disease cases can be avoided if there is no family history in population
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