Treating sinus infections. Sinus infections are common, and doctors often treat

Question

Treating sinus infections. Sinus infections are common, and doctors often treat them with antibiotics. Another treatment is to spray a steroid solution into the nose. A well designed clinical trial found that these treatments, alone or in combination, do not reduce the severity or the length of sinus infections. The clinical trial was a completely randomized experiment that assigned 240 patients at random among 4 treatments as follows: (a) What are the factors and treatments in this experiment? (b) Outline the design of the experiment. (c) Explain briefly how you would do the random assignment of patients to treatments. If the random assignment of patients to treatments in the previous exercise did a good job of eliminating bias, possible lurking variables such as smoking history, asthma, and hay fever should be and comparing many such

Explanation / Answer

a) The factors are the sprays and pills . Treatments are 4 combinations of sparys and pills. which is

steroid spray antibiotic pill

placebo spray antibiotic pill

steroid spray placebo pill

placebo spray placebo pill

b)

Th design is as follows

we have mainly 2 factors : spray types and pill types

where each factor has 2 levels of treatments namely

steriod, placebo for spray and antibiotic , placeo for pills

c)

Randomization of experiment means that we need to randomly assign people to each of the 4 combinations as described in part a. There should not be any bias wrt to age , gender , location etc

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