Proteins in a family of transcription factors (DNA binding molecules that activa

Question

Proteins in a family of transcription factors (DNA binding molecules that activate transcription) have 2 distinct domains: activation domain (AD) and DNA binding domain (DBD). These are not steroid hormone receptors since they do not require hormone binding to do their job. While studying a transcription factor (XP) you discover that if you break these two domains apart and attach them to two separate molecules (Y and Z) the transcription factor would still function as long as Y and Z bind to each other.

Which of the following would probably be true about this system? Explain each briefly. (8)

A.The AD and DBD cannot truly be considered

Explanation / Answer

Based on your data, transcription factors have two types of domains:

The given transcription factors in data are not steroid hormone receptors; hence they do not have Hormone binding domain or AD. In this study, the transcription factor (XP) has one domain called DBD, because it is a not steroid hormone receptor.

“If we separate domains, the transcription factor will be losing its activity.” Then we were separated XP domains and attached with other two other molecules called Y and Z. Therefore, it form a complexe called: Z:XP-DBD-Y. However, transcription factor would still function as long as Y and Z bind to each other.      

The true statements regarding this system are:

A) The AD and DBD cannot truly be considered “domains:”

This is an incorrect (false) statement, because they are two independent domains. If both AD and DBD present in a single domain, then we could not separate them properly into individual ones.       

B) If you mutate Z so that Y and Z no longer bind each other than Z: XP-DBD would not still bind DNA appropriately:

It is a true statement, because the transcription factor (XP) as long as Y and Z bind to each other.

C) XP has a 3-dimensional structure identical to the other transcription factors in the family:

It is a true statement, because all most all transcription factors have 3-dimensional structures, which allow them to bind with DNA and other ligands.

D) This would probably work in a similar manner for the other transcription factors in this family:

It is a false statement, because every transcription factor has specificity and individual properties.

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