Ethics Case Study: Design and Analysis of Preclinical Research Studies Carla is

Question

Ethics Case Study: Design and Analysis of Preclinical Research Studies

Carla is a post-market statistician at PharmCo--a mid-size pharmaceutical company that makes over-the-counter pain medications (e.g. ibuprofen). For the most part, she monitors incidence of side-effects reported by comsumers (e.g. upset stomach, heartburn, dizziness). Carla likes her job and finds it rewarding to feel like her work contributes to medicine that helps people. She has also developed a reputation in the company as a careful and talented statistician. A few months after her friend Elijah leaves PharmCo for a job with the pharmaceutical giants PharmTech, he contacts Carla about a job opening as lead statistician in a pre-clinical research arm of the company. The job is a big promotion, and PharmTech has a great reputation for a patient-centered culture and develops life-saving medications used to treat late-stage cancers and severely debilitating medical conditions.

After a bit of research, Carla learns that pre-clinical research at a company like PharmTech usually involves animal research. Carla always thought herself to be against animal research, because she didn't feel that animals should have to suffer for the comfort and benefit of humans. On the other hand, the pre-clinical research phase is mandated by the federal government during early research, so the important medicines made by PharmTech cannot otherwise exist to help the people that depend on them.

What should Carla do? Answer each of the questions in the following ethical framework to structure your response.

1. What is the perceived problem or ethical dilemma?

2. What facts do we know (list as many as you can)?

3. What stakeholders, values, and guidelines are involved?

4. What are some options (list at least 4—including both good & bad options)?

5. Consider the options (outcomes, virtues, consequences)?

6. Which is the BEST (or even "least bad") option?

7. How might we prevent this in the future (if possible)?

Explanation / Answer

1) The perceived problem is "Animal Life"

Carla working as a statistician at PharmCo--a and she like her job.

Carla also getting a big opportunity to work with reputed company PharmTech with good position.

PharmTech work for a patient-centered culture and develops life-saving medications used to treat late-stage cancers and severely debilitating medical conditions.

But Carla get to know that PharmTech involves animal research to which she always against. but animal research is mandatory to drug testing before testing on human.

2)

Invention of new medicines is become a need.

preclinical trials are for to check early evidence of toxicity and side effects.

animal testing is necessary in preclinical trial.

animals have short life span as compare with human.

it is necesary to test drug on live thing before humans testing.

3)

pre-clinical research phase is mandated by the federal government during early research.

4)

a)try to redevlope old medicines for perticular disease so, bit level preclinical study avoid.

b)try to find out result on less amount of animal.

c)try to find remedy for animals who are undergo testing so they won't die.

d)stop unnecessary invention of new drug just for business where good drugs are in market for that drug.

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