Example Problem 12.33 Spinocerebellar ataxia type 1 is a neurodegenerative disea

Question

Example Problem 12.33
Spinocerebellar ataxia type 1 is a neurodegenerative disease marked by the gradual loss of motor skills and culminating in early death. It is caused by an expanded CAG repeat in the coding region of the Ataxin 1 gene. Fryer et al. (2011) investigated the possible benefits of excercise in treating the disease. They used a mild excercise regimen in a mouse model of the disease (a mouse strain in which an expanded CAG repeat was “knocked in” to the mouse version of the same gene, and that had similar symptoms).

a. What is the basic question the researchers are asking?

b. Name the explanatory/response variables and the scale on which they're quantified.

c. What type(s) of statistical model(s) makes sense for these data?

d. What type of plot might you provide to show the data in the analysis?

Explanation / Answer

a) The basic question being asked is whether the effect of neurodegenerative disease marked by the gradual loss of motor skills and culminating in early death because of an expanded CAG repeat in the coding region of the Ataxin 1 gene(dependent variable) can be reduced or prevented by exercising(independent variable).

b)Explanatory/response variables is mild exercise regimen in a mouse model of the disease (a mouse strain in which an expanded CAG repeat was “knocked in” to the mouse version of the same gene, and that had similar symptoms)

C) comparison of means by any nominal or ordinal test will be suitable.

d) A box plot would be suitable.

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