8.46) What is your best estimate of the percent change in urinary protein based

Question

8.46) What is your best estimate of the percent change in urinary protein based on the data in Table 8.16?

8.47) Provide a 95% Cl associated with your estimate in problem 8.46.

Renal Disease Ten patients with advanced diabetic nephropathy (kidney complications of diabetes) were treated with captopril over an 8-week period [9]. Urinary protein was measured before and after drug therapy, with results listed in Table 8.16 in both the raw and In scale. Changes in urinary protein after treatment with captopril TABLE 8.16 Raw scale urinary protein g/24 hr) In scale urinary protein In (g/24 hr) Patient Before Before 25.6 17.0 16.0 10.4 8.2 7.9 5.8 5.4 5.1 4.7 10.1 5.7 5.6 3.4 6.5 0.7 6.1 4.7 2.0 2.9 3.24 2.83 2.77 2.34 2.10 2.07 0.36 1.76 1.69 1.63 1.55 2.31 1.74 1.72 1.22 1.87 3 5 1.81 1.55 0.69 1.06 8.44 What is the appropriate statistical procedure to test whether mean urinary protein has changed over the 8-week period? 8.45 Perform the test in Problem and In scale, and report a p-value. Are there any advantages to using the raw or the In scale? 8.46 What is your best estimate of the percent change in urinary protein based on the data in Table 8.16? *8.47 Provide a 95% Cl associated with your estimate in Problem 8.46 8.44 using both the raw

Explanation / Answer

8.44:

Paired T-Test and CI: Before, After

Paired T for Before - After

N Mean StDev SE Mean
Before 10 10.61 6.86 2.17
After 10 4.77 2.67 0.85
Difference 10 5.84 5.29 1.67

95% CI for mean difference: (2.05, 9.63)
T-Test of mean difference = 0 (vs not = 0): T-Value = 3.49 P-Value = 0.007

Hope this will be helpful. Thanksa nd God Bless You :-)

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