The amino acid sequence shown below represents a portion of apeptide bond obtain

Question

The amino acid sequence shown below represents a portion of apeptide bond obtained from a large protein: 1    2   3      4    5     6    7      8    9    10   11   12 His-Ile-Thr-Arg-Phe-Phe-Pro-Cys-Met-Gly-Glu-Ala- 13   14   15   16   17   18   19   20   21 22  23   24 Ile-Pro-His-Thr-Glu-Asp-Cys-Gln-Met-Ile-His-Cys- 25   26   27   28   29   30 Pro-Arg-Lys-Gln-Pro-Tyr a. Determine where the chain would be more likely to show bends or reverse turns. Provide a clear explanationfor your answer. b. Discuss where one would find cross-linked disulphide bondsin this sequence. c. Would you consider this molecule to be in -helixformation? Explain. Please help! Will rate lifesaver. The amino acid sequence shown below represents a portion of apeptide bond obtained from a large protein: 1    2   3      4    5     6    7      8    9    10   11   12 His-Ile-Thr-Arg-Phe-Phe-Pro-Cys-Met-Gly-Glu-Ala- 13   14   15   16   17   18   19   20   21 22  23   24 Ile-Pro-His-Thr-Glu-Asp-Cys-Gln-Met-Ile-His-Cys- 25   26   27   28   29   30 Pro-Arg-Lys-Gln-Pro-Tyr a. Determine where the chain would be more likely to show bends or reverse turns. Provide a clear explanationfor your answer. b. Discuss where one would find cross-linked disulphide bondsin this sequence. c. Would you consider this molecule to be in -helixformation? Explain. Please help! Will rate lifesaver.

Explanation / Answer

a) the chain would be more likely to show turns at theproline residues.The reason is that both glycine and prolineresidues often occur in turns. b)the cross linked disulphide bonds would be between 2cycteine molecules.The most probable place would be between thecysteine at 8th position and the cysteine at 19th position. c) this molecule cannot be in the helix formation.thisis due to the many number of proline residues in themolecule. a proline residue introduces a destabilizing kink in the helix.so that is why this molecule cannot form the helix.

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