A randomized trial studied 242 HIV-seropositive, 2nd-trimester pregnant women to
ID: 3435376 • Letter: A
Question
A randomized trial studied 242 HIV-seropositive, 2nd-trimester pregnant women to assess the efficacy of zidovudine (AZT) in preventing perinatal HIV transmission. Results were:
Zidovudine
Placebo
All
Births (#)
121
121
242
Infection status of infant
Non-infected (#)
112
90
202
Infected (#)
9
31
40
Transmission rate (%)
7.4
25.6
16.5
Which one answer best describes the data in the
Zidovudine
Placebo
All
Births (#)
121
121
242
Infection status of infant
Non-infected (#)
112
90
202
Infected (#)
9
31
40
Transmission rate (%)
7.4
25.6
16.5
Explanation / Answer
a)Count best describes the non-infected row in the table as it is calculated out of total of 242
b)Here in the trans missionr rate the best it describes is the proportion as
c) relative risk of HIV infection for infants whose mothers took zidovudine relative to infants of mothers who took placebo =(transmission rate of zidovudine)/(transmission rate of placebo)=7.4/25.6 =.289
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