Determine the type(s) of chromosomal Consider two non -homologous chromosomes wh

Question

Determine the type(s) of chromosomal

Consider two non -homologous chromosomes whose normal sequences of segments and centromere locations are shown here Chromosome 1 A B C ? D E F G H Chromosome 2 Q R ? S T U V Determine the type (or types) of chromosomal structural changes necessary to produce the following chromosomes. a. S T U V ? D E F G H b. A B V T E D ? C Q R . S F G H Note: You have to be specific. For example, it is not enough to say a deletion and then a pericentric inversion. You have to include the exact genes involved in the chromosomal aberrations. For example, deletion of FG from chromosome 1, then a reciprocal translocation of AB and OT between the two chromosomes, etc.

Explanation / Answer

Deletion - mutation

A deletion changes the number of DNA bases by removing a piece of DNA thus forming a mutant. Small deletions may remove one or a few base pairs within a gene, while larger deletions can remove an entire gene or several neighboring genes. The deleted DNA may alter the function of the resulting protein(s) (mutation) may be dormant or may be lethal.

a and b are translocated and inversed

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