To test whether a particular molecule acts as the classical neurotransmitter (NT

Question

To test whether a particular molecule acts as the classical neurotransmitter (NT) at a CNS synapse, one would perform the following test:

A) Determine whether the NT is found in the nucleus of the presynaptic neuron

B) Apply a synthetic version of the NT directly to a dendrite or cell body of the postsynaptic neuron and determine if it mimimcs the normal PSP

C) Apply a specific blocker of the receptor for the NT to the postsynaptic neuron and determine if it mimics the normal PSP

D) Determine whether the NT is found in the cell body of the postsynaptic neuron

Please choose the correct answer and explain why it is correct.

Explanation / Answer

A neurotransmitter (NT) is a small molecule released at the presynaptic axonal membrane of one neuron into the synaptic cleft to bind with the receptors present in the postsynaptic membrane of another neuron (or muscle fiber), which results in either excitation or inhibition of the passage of signals across the synapse.

B is the answer Action on postsynaptic cell. Exogenous application of the substance in appropriate amounts mimics the action of the endogenously-released substance on the postsynaptic cell or organ.

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