In a study of normal renal function the urine flow rate of a patient is 2.0 mL/m

Question

In a study of normal renal function the urine flow rate of a patient is 2.0 mL/min, the glomerular filtration rate of 100 mL/min, and renal plasma flow is 500 mL/min. During this time, Substance X is infused and a steady state is achieved. The afferent arteriolar concentration of X is 100 mg/dL, the efferent arteriolar concentration is 120 mg/dL, and the renal vein concentration is 102 mg/dL. From these data you can conclude that X is?

aFreely filtered and reabsorbed
bFreely filtered and secreted
cFreely filtered, but neither reabsorbed nor secreted
dNot filtered, but secreted
e. Not filtered or secreted

how do i solve this problem

Explanation / Answer

The substance x is given and it achieved the steady state. It enters the systemic circulation. Within a nephron inside the glomerulus the blood enters the glomerulus via afferent arteriole. The concentration of substance x is 100mg/ dl. The substance should be filtered inside the glomerulus and it should enter inside the nephron so that it must be excreated in urine . But the concentration of substance x in the efferent arteriole is 120mg/ do which is higher than the concentration in afferent arteriole. That means that the substance is not filtered via glomerulus and it is secreated in the systemic circulation as the concentration is increased in the renalvein i.e. 102mg/ do.

So the correct option for the above situation is d

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