Chapter 20 Art-labeling Activity Figure 20.10 Resources « previous | 30 of 49 |

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Chapter 20 Art-labeling Activity Figure 20.10 Resources « previous | 30 of 49 | next » Drag the labels onto the diagram to identify steps in response to low blood pressure Origin Inactive precursor protein Blood n made by liver Chemical nature-amino-acid peptide Cardio- vascular control center ACE (enzyme) Liver Biosynthesis Increased Na reabsorption Transport in the Dissolved in plasma direct effect NaCl Half-life 1 min (renin half-life: 10-20 min) in the plasma Renin (enzyme) Factors affecting Blood pressure (via renin) release Control pathwayRenin-angiotensin system Target cells or Paracrines Decreased GFR Adrenal cortex, arterioles, brain tissues Macula densa of distal tubule ANG Iin plasma Receptor AT receptors ^ 4d 11:33PM 71 Search Windows

Explanation / Answer

Each higlihted text represent the labels in a box which can be dragged to corresponding places.

Reduced blood pressure results in the decreased GFR which reduces the NaCL transport across the macula densa of distal tubule. Cardiovascular control center in respose to low blood pressure have increased sympathetic activity. Both increased NaCL transport and increased sympathetic activity stimulates the granule cells of afferent arteriole to produce renin (enzyme). Liver constantly produces angiotensinogen in plasma which is converted by renin to ANG1.The ACE (enzyme) then act on ANG1 to convert it to ANGII in plasma

ANG II have several effects as follows

It activates Arterioles for vasoconstrion and thereby increased blood pressure. Activates cardiovascular center of medulla oblongata and increased cardiovascular response leading to increased blood pressure. Act on hypothalamus for increased vassopressin secretion and increase in thirst. Activates adrenal cortex for increased aldosterone secretion followed by increased Na ion resorption and increased volume and maintain osmolarity and ultimately to increased blood pressure. Act on proximal tubules for increased Na ion resorption and thereby to increased volume and maintain osmolarity and finally increased blood pressure.

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