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91188696 Part E ne Pubends with type 2 diabetes usually searete Iui but thare is

ID: 3480609 • Letter: 9

Question

91188696 Part E ne Pubends with type 2 diabetes usually searete Iui but thare is decreased respomsiveness in larget cols. Common drugs used to treat type 2 datetes work by simulating beta cell secretion of insulin, enhancing the action of iain on muscle and fat cells, decreasing the amound of glucose produced by the frer, er other Tenzin was prescribed an oral sulonylarea Sulfonylurea drugs work by stimulating beta cells to secrete insule. Belore examining how these drugs work, lefs Review the signaling mechanisms by which elevated blood glucose results in insulin secretion. normal imulin secreson Hints Reset Help increased 1. With increased blood glucose, there will be acitated dfusion of gkicose into beta production of ATP in beta cells 2 This change in facilitated diffusion will lead to 3 This change in ATP will lead to 4. This change in potassium channels will lead to numbers of open potassium channels itusion of potassium out of beta cels 5. This change in potassium channels will lead ta levels of intracellular potassium 6. This change in intracelular potassium will lead to depolarization positive change in beta cells and 7 This depolarization of beta cells lead to numbers of open calclue channels 8 This change calcium channels will lead to levels of intracellular calckum 9. This change in intracelular calcium will lead to secretion of insulin SubornitMy Answers Give Up Part F S-5

Explanation / Answer

1. With increased blood glucose there will be increased facilitated diffusion of glucose into beta cells.

2.The change in facilitated diffusion will lead to increased production of ATP in beta cells.

3. The change in ATP will lead to increased number of open K+ channels.

4.The change in potassium channel will lead to increased diffusion of potassium out of beta cells.

5. The change in potassium channel will lead to decreased levels of intracellular potassium

6. This change in intracellular potassium will lead to decreased positive charge in beta cells and depolarization.

7. The depolarization of beta cell will lead to increased number of open calcium channels.

8. The change calcium channels will lead to increased levels of intracellular calcium.

9. The change in intracellular calcium will lead to increased secretion of insulin.