Describe the oxyhemoglobin dissociation curve in the following: what does the gr

Question

Describe the oxyhemoglobin dissociation curve in the following:

what does the graph explain under normal conditions

I have the below info but need one paragraph in own words.

Factors affecting oxyhemoglobin dissociation curve:

The oxygen dissociation curve can be shifted right or left by a variety of factors. A right shift indicates decreased oxygen affinity of hemoglobin allowing more oxygen to be available to the tissues. A left shift indicates increased oxygen affinity of hemoglobin allowing less oxygen to be available to the tissues.

Explanation / Answer

Oxyhemoglobin dissociation curve is a sigmoid curve which represents the relationship between Oxygen concentration & its level of saturation in Hemoglobin. In other terms, the amount of oxygen available to the amount of oxygen binding (carried ) to the hemoglobin molecule.

In the graph, the x-axis represents the amount of (Partial Pressure, PaO2) oxygen & y-axis represents the oxygen saturation (SaO2).

In conditions like acute alkalosis, hypothermia,& abnormal hemoglobin like Carboxy Hemoglobin, Methemoglobin, the hemoglobins attraction towards oxygen increases leading to increased binding of the oxygen molecule to hemoglobin, but not being or less released to the tissues. This makes the curve to shift towards the left.

In conditions like acute acidosis, hyperthermia, the affinity towards oxygen reduces leading to less binding & quicker release to the tissue, resulting in the curve shifting towards the right.

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