Circle the answer (high, low or normal) for each of the questions below. a) If a
ID: 3482049 • Letter: C
Question
Circle the answer (high, low or normal) for each of the questions below.
a) If a person has primary hypocortisolism, would their levels of ACTH be high, low or normal?
b) If a person has secondary hypothyroidism due to a problem with the pituitary gland, would their levels of TRH be high, low or normal?
c) If a person has secondary hypercortisolism due to a problem with their hypothalamus, would their levels of CRH be high, low or normal?
d) If a person has primary hypercortisolism, would their levels of CRH be high, low or normal?
e) If a person has Grave's Disease, would their levels of TRH be high, low or normal?
f) If a person has Addison's Disease, would their levels of ACTH be high, low or normal?
Explanation / Answer
a) If a person has primary hypocortisolism, their ACTH would be high.
Primary hypocortisolism is due to decreased production of cortisol, the cause being defective function of adrenal gland, per se. this is otherwise named as Addison’s disease.
b) If a person has secondary hypothyroidism due to a problem with the pituitary gland, their TRH would be high.
Problem with pituitary gland causes decreased production of TSH, thus decreasing thyroid hormone secretion from thyroid gland. This in turn, stimulates hypothalamus, producing more TRH.
c) If a person has secondary hypercortisolism due to a problem with their hypothalamus, their levels of CRH would be high.
CRH is produced by the hypothalamus, thus when CRH secretion increases, that stimulates pituitary to produce ACTH, which in turn, increases production of cortisol from adrenal cortex.
d) If a person has primary hypercortisolism, their levels of CRH would be low.
Primary hypercortisolism/Cushing’s disease is due to defective adrenal cortex, producing more cortisol, without any stimulation from pituitary or hypothalamus.
High cortisol negatively feeds back on hypothalamus, decreasing CRH level.
e) If a person has Grave's Disease, their levels of TRH would be low.
In Grave’s disease, there is production auto antibodies against TSH receptors, thus hyperstimulating the thyroid, producing more T3 and T4.
High level of thyroid hormone negatively feeds back on hypothalamus, decreasing TRH level.
f) If a person has Addison's disease, their ACTH levels would be high.
Addison's disease is due to decreased production of cortisol, the cause being defective function of adrenal gland, per se.
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