Change in EPSP Magnitude resulting from spike timing during induction 200 T Ato

Question

Change in EPSP Magnitude resulting from spike timing during induction 200 T Ato At>o 180 160 co 140 120 u 100 E 80 E 60 & 40 20 0 100 -75 -50 -25 0 25 50 75 100 At during induction 2. 1pt: Is this a Hebbian or anti-hebbian synapse? anti-n1bbia n 3. 1pt: Does the synapse have a bias? If yes, what is it? 4. 1pt: If the presynaptic cell fires 50ms before the post synaptic cell, how will the magnitude of the EPSP change? ie 1pt: What if the presynaptic cell fires 30ms after the post synaptic cell-how will the magnitude of the EPSP change then? 5. 1r will be 110% fC baseline

Explanation / Answer

In neuroscience, an excitatory postsynaptic potential (EPSP) is a postsynaptic potentialthat makes the postsynaptic neuron more likely to fire an action potential. This temporary depolarization of postsynapticmembrane potential, caused by the flow of positively charged ions into the postsynaptic cell, is a result of opening ligand-gated ion channels. These are the opposite of inhibitory postsynaptic potentials (IPSPs), which usually result from the flow of negative ions into the cell or positive ions out of the cell. EPSPs can also result from a decrease in outgoing positive charges, while IPSPs are sometimes caused by an increase in positive charge outflow. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC).

We review biophysical models of synaptic plasticity, with a focus on spike-timing dependent plasticity (STDP). The common property of the discussed models is that synaptic changes depend on the dynamics of the intracellular calcium concentration, which itself depends on pre- and postsynaptic activity. We start by discussing simple models in which plasticity changes are based directly on calcium amplitude and dynamics.

2. Hebbian theory is a theory in neurosciencethat proposes an explanation for the adaptation of neurons in the brain during the learning process. It describes a basic mechanism for synaptic plasticity, where an increase in synaptic efficacy arises from the presynaptic cell's repeated and persistent stimulation of the postsynaptic cell.

So the synapse is anti hebbian synapse.

3. Yes the synapse has the bias.The term that most scientists use to describe a synapse's "bias" is synaptic strength. The strengths of synapses depend on their "history". The change of synaptic strength is called synaptic plasticityGenerally, the strength of a synapse, i.e. the size of the effect of a presynaptic stimulus on the postsynaptic neuron depends on presynaptic and postsynaptic factorsLong-term potentiation (LTP) is a persistent increase in synaptic strength following high-frequency stimulation of a chemical synapse.In neuroscience, long-term potentiation (LTP) is a persistent strengthening of synapsesbased on recent patterns of activity. These are patterns of synaptic activity that produce a long-lasting increase in signal transmission between two neurons.so the synapse bias is LTP ( long term potential) based.

4. If the presynaptic cell fires 50 ms before than the postsynaptic cell the magnitude of epsp chages and it becomes less due to the prior activation of presynaptic cell. As a single epsp cannot fire the action potential in the membrane. It is decreased to the 85% of the baseline.

5. And if the postsynaptic cell blows previously then the magnitude will be 180% of the baseline.

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