Circle the answer (high, low or normal) for each of the questions below. a) If a

Question

Circle the answer (high, low or normal) for each of the questions below.

a) If a person has primary hypocortisolism, would their levels of ACTH be high, low or normal?

b) If a person has secondary hypothyroidism due to a problem with the pituitary gland, would their levels of TRH be high, low or normal?

c) If a person has secondary hypercortisolism due to a problem with their hypothalamus, would their levels of CRH be high, low or normal?

d) If a person has primary hypercortisolism, would their levels of CRH be high, low or normal?

e) If a person has Grave's Disease, would their levels of TRH be high, low or normal?

f) If a person has Addison's Disease, would their levels of ACTH be high, low or normal?

Explanation / Answer

a) high .(As disease is in adrenal gland ,cortisol levels are low so ACTH level will be high to stimulate the adrenal gland to produce more cortisol)

B) high( pituitary gland is not working so there will be low TSH and thus low t3,t4 so in response there will be high TRH)

C)high(CRH level will be high as it is released from hypothalamus and there is disease in hypothalamus which may be a tumour which is releasing high CRH and thus high ACTH and thus high cortisol)

D low(disease is in adrenal gland so high levels of cortisol result in negative feedback inhibition of hypothalamus resulting in lower level of CRH)

E) low(due to negative feedback inhibition )

F) high(as disease is in adrenal gland ,cortisol levels are low so ACTH levels will be high to stimulate the adrenal gland to release more cortisol)

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