4. A possible consequence of staphylococcal infections is glomerulonephritis Glo

Question

4. A possible consequence of staphylococcal infections is glomerulonephritis Glomerulonephritis affects the filtration membrane by causing the basement membrane underlying the glomerular endothelium to lose its negative charge The negative charge on the basement membrane is what prevents plasma proteins form entering the filtrate. Thus, with this condition, proteins can enter the urine (proteinuria). What effect will this have on glomerular filtration rate? Why? Again, be as specific as possible.

Explanation / Answer

Proteinuria is a general characteristic in most of the kidney diseases observed in many patients.It leads to decreased glomerular filterate rate because the protein in the filterate cause inflammation and scarring in renal tubules.

Plasma proteins generally contribute to glomerular oncotic pressure which is a major force opposing filteration.As proteins are not normally found in filterate, the oncotic pressure of Bowman's capsule is much lower than oncotic pressure of glomerulus.Due to this,oncotic pressure of Bowman's capsule favours filteration.This there by forms many cosequences of proteins leaking into filterate which are two fold.It includes oncotic pressure of glomerulus decreases due to loss of proteins and oncotic pressure of Bowman's capsule increases due to gain of proteins.From this, it can be concluded that the overall effect of movement of proteins has an increase in glomerular filterate rate from glomerulus to Bowman's capsule.

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