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An investigator designs a randomized trial to test whether experimental therapy

ID: 3485896 • Letter: A

Question

An investigator designs a randomized trial to test whether experimental therapy A is superior to standard therapy B in treating disease Z. The investigator randomly assigns 100 individuals to therapy A and 100 individuals to therapy B. After 3 months, 30 individuals receiving therapy A stop taking therapy A. After 6 months, the investigator compares disease Z status between individuals assigned to therapies A and B. Based only on the information provided, which of the following statements is most likely to be correct? (1 pt) A. The results obtained from the randomized trial are valid because of the planned crossover B. The results obtained from the randomized trial may not be valid because the investigator did not use a factorial design C. The results obtained from the randomized trial may not be valid because stratified randomization was not used D. The results obtained from the randomized trial may not be valid because noncompliance occurred

Explanation / Answer

A. The results obtained from the randomized trial are valid because of the planned crossover.

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