The disease cholera causes an imbalance in osmotic equilibrium and dehydration o

Question

The disease cholera causes an imbalance in osmotic equilibrium and dehydration of the cholera victim. It is caused by the bacterium Vibrio cholerae. The bacteria produce an endotoxin that activates cAMP production/activity in intestinal epithelial cells that line the lumen of the small intestine. cAMP inhibits sodium uptake and increases chloride secretion by the epithelial cells. This causes and electrolyte imbalance and the diarrhea observed with the disease.

In terms of osmolarity/tonicity why would the intestinal cells’ reabsorption of water decrease?

What then would happen to the interstitial fluid? Would other cells be affected too? Explain your answers.

Explanation / Answer

Cholera is an acute diarrheal condition which is fatal in severe cases where the huge fluids loss occur.

About interstitial fluid:-

The best treatment for the cholera is providing oral rehydration therapy.

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