A batch of 150 capsules containing 50 mg of drug are required. The only source o

Question

A batch of 150 capsules containing 50 mg of drug are required. The only source of drug available to you are tablets with a mass of 140 mg that contain 100 mg of drug a) What is the minimum number of tablets required to make the formulation? b) How much diluent is required to make the formulation using dependent filling if size 1 capsules which can hold 350 mg of formulation are used? Choose one answer from A and one answer from B. Select one or more: O a. b) 52.5 g diluent O b. b) 45 g diluent O c. b) 42 g diluent O d. b) 32.5 g diluent Oe. a) 75 tablets O f. a) 74 tablets O g. a) 100 tablets O h. a) 140 tablets

Explanation / Answer

The total amount of drugs required in mg = no. of tablets * mass of drug = 150 * 50 = 7500 mg

Now, in second case the mass of 1 tablet = 140 mg and mass of drug in 1 tablet = 100 mg.

So, the amount of dilutent in 1 tablet = 40 mg.

The minimum number of tablets required to make the formulation is

( total amount of drugs / mass of 1 drug in tablet )

=> (7500 mg / 100 mg) = 75 tablets

So, for A correct option is e. 75

Now,

140 mg tablet contain 100 mg drug

350 mg capsule contains ( 100 / 140) * 350 mg = 250 mg

Amount of drug capsule can hold = 250 mg

No of capsules required for formation = total amount of drug required / amount of drug it can hold

= 7500 mg / 250 mg = 30 capsules

So, amount of dilutent in 1 capsule 250 mg

Amount of cdilutent required 350 mg * 150 = 52,500 mg = 52.5 g

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